منابع مشابه
MR mismatch and thrombolysis: appealing but validation required.
Since the initial description of the ischemic penumbra 30 years ago, the concept of rapid restoration of blood flow to threatened brain tissue has been the “holy grail” of acute stroke therapy.1,2 Despite its drawbacks, MR imaging of perfusion diffusion mismatch remains the most widely used and practical means of in vivo assessment. There is accumulating evidence linking reperfusion with better...
متن کاملMR mismatch is useful for patient selection for thrombolysis: no.
The MR perfusion diffusion (PI/DWI) mismatch concept for the selection of patients for intravenous thrombolysis (IVT) was introduced with several smaller case series in the late 1990s and early 2000s,1 followed by larger series by many international groups over the last 8 years. A potentially salvageable penumbra was operationally defined as a PI/ DWI-(volume) mismatch where PI indicates the hy...
متن کاملMismatch-based delayed thrombolysis: a meta-analysis.
BACKGROUND AND PURPOSE Clinical benefit from thrombolysis is reduced as stroke onset to treatment time increases. The use of "mismatch" imaging to identify patients for delayed treatment has face validity and has been used in case series and clinical trials. We undertook a meta-analysis of relevant trials to examine whether present evidence supports delayed thrombolysis among patients selected ...
متن کاملMRI mismatch-based intravenous thrombolysis for isolated cerebellar infarction.
BACKGROUND AND PURPOSE Cerebellar infarctions constitute a significant proportion of ischemic strokes and carry a substantial morbidity and mortality mainly because of swelling in the posterior fossa. No specific acute therapy is established, and patients are usually excluded from intravenous thrombolysis (IVT). METHODS Two patients presented in an extended time window of 5 and 7 hours to our...
متن کاملMR imaging-guided intravenous thrombolysis in posterior cerebral artery stroke.
PCA stroke was under-represented in or excluded from the clinical trials examining thrombolysis based on the PWI-DWI mismatch concept. We present 6 patients with PCA stroke treated with thrombolysis in an extended time window by using MR imaging criteria. Symptoms included aphasia, sensorimotor hemiparesis, hemineglect, and homonymous hemianopia. Initial MR imaging demonstrated circumscribed is...
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ژورنال
عنوان ژورنال: Stroke
سال: 2009
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.109.552893